Public workshop to discuss proposed amendments to the California emission control system warranty regulations and maintenance provisions for on road heavy duty vehicles with gross vehicle weight ratings greater than 14,000 lbs.
Benchmark Results: The overall Anvil SSD Benchmark score with the Applications benchmark was 5,668.33 on the Samsung SM951 NVMe 256GB M.2 PCIe SSD with 100% compression. This score is about half of what we expected as again we ran into write performance issues on this benchmark.
Benchmark Results: We wanted to check out the File Benchmark test in HD Tune Pro, so we fired up HD Tune Pro 5.50 and found that the drive had a sequential read speed of 1701MB/s and a write speed of 1230MB/s according to this utility. The HD Tune 4K Random Multi test with a QD of 32 showed that the drive had 145,000 IOPS read and 5,300 IOPS write.
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Background: The use of warfarin in patients with atrial fibrillation (AF) and chronic kidney disease (CKD) can be problematic because of increased bleeding risk. We performed a systematic review and meta-analysis of observational studies that evaluated the use of warfarin in patients with AF and CKD to evaluate the risks of ischemic stroke/thromboembolism, major bleeding, and mortality.
Methods: PUBMED, EMBASE, CINAHL, ProQuest, and Google Scholar databases were electronically searched through January 12, 2015. Additionally, a manual search was performed for relevant references. Random-effects model was used to estimate the pooled hazard ratio (HR) with 95% CI. CKD was divided into non-end-stage CKD and end-stage CKD (on renal replacement therapy) and separate analyses were performed.
Results: Thirteen publications from 11 cohorts (six retrospective and five prospective) including >48,500 total patients with >11,600 warfarin users were included in the meta-analysis. In patients with AF and non-end-stage CKD, warfarin resulted in a lower risk of ischemic stroke/thromboembolism (HR, 0.70; 95% CI, 0.54-0.89; P = .004) and mortality (HR, 0.65; 95% CI, 0.59-0.72; P < .00001), but had no effect on major bleeding (HR, 1.15; 95% CI, 0.88-1.49; P = .31). In patients with AF and end-stage CKD, warfarin had no effect on the risks of stroke (HR, 1.12; 95% CI, 0.69-1.82; P = .65) and mortality (HR, 0.96; 95% CI, 0.81-1.13; P = .60), but increased the risks of major bleeding (HR, 1.30; 95% CI, 1.08-1.56; P = .005).
The RB951Ui-2HnD is a wireless SOHO AP with a new generation Atheros CPU and more processing power. It has five Ethernet ports, one USB 2.0 port and a high power 2.4GHz 802.11b/g/n wireless AP with antennas built in.It has a 600MHz CPU,128MB of RAM and PoE output function for port #5 - it can power other PoE capable devices with the same voltage as applied to the unit. Maximum load on the port is 500mA.Package contains RouterBOARD 951Ui-2HnD in a plastic case and power adapter.
The device has an operating system preinstalled and licensed. No separate purchase is necessary and the product is ready to use. The device includes free software updates for the life of the product or a minimum of 5 years starting from date of purchase..
Objective: Takayasu's arteritis (TAK) is a large vessel vasculitis with important infiltration of proinflammatory T cells in the aorta and its main branches, but its aetiology is still unknown. Our work aims to explore the involvement of Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) signalling pathway in proinflammatory T cells differentiation and disease activity of TAK.
Methods: We analysed transcriptome and interferons gene signatures of fluorescence-activated cell sorting (FACS-sorted) CD4+ and CD8+ T cells from healthy donors (HD) and in 25 TAK (median age of 37.6 years including 21 active TAK with National Institutes of Health (NIH) score >1). Then we tested, in vitro and in vivo, the effects of JAK inhibitors (JAKinibs) in TAK.
Results: Transcriptome analysis showed 248 and 432 significantly dysregulated genes for CD4+ and CD8+ samples between HD and TAK, respectively. Among dysregulated genes, we highlighted a great enrichment for pathways linked to type I and type II interferons, JAK/STAT and cytokines/chemokines-related signalling in TAK. We confirmed by Real Time Reverse Transcription Polymerase Chain Reaction (RT-qPCR) the upregulation of type I interferons gene signature in TAK as compared with HD. JAKinibs induced both in vitro and in vivo a significant reduction of CD25 expression by CD4+ and CD8+ T cells, a significant decrease of type 1 helper T cells (Th1) and Th17 cells and an increase of Tregs cells in TAK. JAKinibs also decreased C reactive protein level, NIH score and corticosteroid dose in TAK patients.
Like its AHCI-based equivalent, the SM951-NVMe uses the L1.2 low-power standby mode, allowing all high-speed circuits to be turned off when the host computer is in sleep mode or in hibernation. As a result, the overall power consumption SM951-NVMe is significantly reduced to under 2mW.
Samsung SM951-NVMe M.2 SSD is much smaller 2.5 inch SSD and offers a thickness of under 4mm. It looks virtually identical to its brethren, lacking any casing, which leaves its components exposed and vulnerable to damage. As a result, users must take care in transporting the device.
The front side of the drive comes with a sticker, which partially covers the NAND chips. This displays various information pertaining to the drive, including the model number and certifications. The side opposite of the connectors sports an M key notch to denote PCIe x4 and SATA compatibility. All capacities use the Samsung UBX 3-Core controller and Samsung 16nm MLC NAND.
In our first test, we measured 2MB sequential performance from Samsung SM951-NVMe, which posted an impressive 1,820.4MB/s read and 1,191.9MB/s write. While the drive had better read activity compared to the PCIe model, it did record weaker write performance.
When looking at 2MB random transfer performance, the Samsung SM951-NVMe again recorded impressive with read and write activity that measured 1,417.9MB/s and 1,076.1MB/s, respectively. The PCIe model measured 1,337.6MB/s read and 1,080.9MB/s and write.
Moving to smaller 4k random transfers (throughput workload), the Samsung SM951-NVMe measured a whopping 13,497.5 IOPS read and 44,510.5 IOPS write easily beating its PCIe brethren, which posted 9,800.2 IOPS for read activity and 34,836.6 IOPS for write activity.
Our next benchmark measured the Samsung SM951 drives in MB/s using the same file size. Here, the Samsung SM951-NVMe boasted read and write performance of 52.72MB/s and 173.87MB/s, respectively, easily taking top spot in both columns. Its PCIe counterpart recorded 38.28MB/s read and 136.08MB/s write.
In our next test, we shifted to a 4K random workload with 100% write activity that scales from 1QD to 64QD. Here, the Samsung SM951-NVMe scaled from 44,899.38 IOPS to an impressive 92,690.58 IOPS. This was nearly 20,000 more throughput than the PCIe model.
Our last series of synthetic benchmarks compare the hard drives in a series of server mixed-workloads with a queue depth of ranging from 1 to 128. Each of our server profile tests has a strong preference towards read activity, ranging from 67% read with our database profile to 100% read in our web server profile.
The first is our database profile, which consists of a 67% read and 33% write workload mix primarily centered on 8K transfer sizes. In this trace, we recorded the Samsung-NVMe with a range of 10,818.31 IOPS to an impressive 108,711.27 IOPS in the terminal queue depths, which was over 30,000 IOPS more than the PCIe version.
The next profile looks at a webserver, with 80% read and 20% write workload spread out over multiple transfer sizes ranging from 512-byte to 64KB. Here, the Samsung SM951-NVMe had an initial throughput of 9,802.45 IOPS and 93,649.20 IOPS in 128QD once again dominating the leaderboard with impressive results.
Our file server profile is read-only with a spread of transfer sizes from 512-byte to 512KB. The Samsung NVMe drive continued it impressive performance while recording a QD1 of 10,224.05 IOPS and a QD128 of 83,059.73 IOPS.
The last profile looks at workstation activity, with a 20% write and 80% read mixture using 8K transfers. In this scenario, the SM951-NVMe unsurprisingly offered a dominating range 10,242.97 IOPS to 118,275.84 IOPS.
The first real-life test is our HTPC scenario. In this test we include: playing one 720P HD movie in Media Player Classic, one 480P SD movie playing in VLC, three movies downloading simultaneously through iTunes, and one 1080i HDTV stream being recorded through Windows Media Center over a 15 minute period. Higher IOps and MB/s rates with lower latency times are preferred. In this trace we recorded 2,986MB being written to the drive and 1,924MB being read.
In our HTPC profile, the SM951-NVMe posted a blistering average speed of 1,210.13MB/s, 26,291 IOPS and 0.296ms in average latency; however, the PCIe version of the SM951 boasted slightly better numbers.
Our second real-life test covers disk activity in a productivity scenario. For all intents and purposes, this test shows drive performance under normal daily activity for most users. This test includes: a three hour period operating in an office productivity environment with 32-bit Vista running Outlook 2007 connected to an Exchange server, web browsing using Chrome and IE8, editing files within Office 2007, viewing PDFs in Adobe Reader, and an hour of local music playback with two hours of additional online music via Pandora. In this trace we recorded 4,830MB being written to the drive and 2,758MB being read. 59ce067264